We stayed at the Main Street from December 25 - 29th. It is a block off Fremont Street, but basically right next door to the Plaza and across the street from the California. So it is right in the mix of things.
It is very close to the interstate, we were on the 17th (top) floor in a King room, that overlooked the interstate, and it is loud. This was really the only negative. Otherwise, it was easy to get to (right off the interstate). Parking was easy in the ramp, although the elevator wasn't working while we were there, so there were times we were on the 4th level and had to take the stairs. Room was nice and clean and looked like it had been updated recently. Shutters on the windows were a nice touch and worked well at keeping light out, something I was a bit worried about. The room was a lot bigger than I thought it would be. I've heard downtown rooms were small, but this was a nice big room.
We ate at the buffet there, actually had Christmas dinner there, and it was really good. Lots of choices, and everything was hot and fresh. Also, the room it is in, is really open and spacious, and has a great antique look to it. We ate at the buffet again later in the week, and it was still good, but nothing like what the Christmas buffet was.
The common areas are really nice, again, keeping with the antique theme. They even have a brochure at the front desk that will show you some of the real antiques they have there.
Overall, this was a nice clean hotel, and for the $40/night we spent was a very good bargain.