I really enjoyed my stay at Thehotel at Mandalay Bay. There were many restaurants onsite, most of which are very expensive. We had no problems with the room or with room service. Getting to the center of the strip can be pricey. We had a hard time deciding what would be more economical - taking the tram or taking a taxi.

This hotel looks fantastic, but sadly its looks are all that impressed. It is aimed at the very young and trendy set for whom quality of service is obviously not important. The reception staff were brusque and service elsewhere in the hotel was perfunctory. None of the smiles that you get elsewhere in Vegas. The hotel had a serious "drain" issue for the 2 days we stayed there - the whole of the large reception area smelled of sewerage which isn't great whilst you're eating breakfast in the hotel cafe. The room was great - we had a suite and it was beautifully appointed, couldn't fault it. However, for the prices they are charging, we expected service more in line with that we received at the Four Seasons. Sharing the lifts with groups of very trendy but very drunk, loud and unsophisticated 20-somethings did not add to the experience. We commented politely when we checked out and were asked if we had enjoyed our stay - they discounted our bill slightly, but we would not return.

A friend of mine was going to a conference at 4 Seasons, and we picked TheHotel b/c it was basically the same price for a suite here vs a room at 4 Seasons (which is within Mandalay Bay). I had read the reviews here and new what to expect.
Check in was painless and quite quick. We got to our room on the 20th floor and as it didn't face the strip, I didn't spend much time staring out at the airport and distant mountains. As has been previously stated, rooms are DARK. Black furniture, dark brown carpets and walls and lights with what seemed to be 20watt bulbs. Energy savings for TheHotel ?
The suite was spacious enough with a full living room and 1.5 bathrooms. The main bathroom might even be too big. The bed was comfortable and the bedding was clean. There was a nice plasma or LCD in the living room, the bedroom and even the bathroom. No coffeemaker though. I find that to be ridiculous.
I also hate to be nickled and dimed, like $20pp per day to use the gym and $15/day for internet.
A number of restaurants are on site. Most are on the pricey end ie $30 for a sushi roll. There was also a restaurant on the top floor, where two appetizers, a martini and a glass of wine ran us $85. The food was great though.
We partied up on theMix on the 62nd floor and there is a great view, but loud. There was also a better(IMO) club on the main casino floor. Great dancing and music and hot women.
I did not use the pools due to the weather, but it looked awesome with the beach entrance and wave machine.
If you want to go to other hotels and casinos and clubs, past the luxor next door, its definitely a hike. We did walk all the way down to Bellagio to check out some of the hotels on the way. This was probably 2-3 miles so certainly not for every one. We did take a cab back though.
All in all I think I would recommend this hotel with some reservations.

This hotel was beautiful and the suites were great. It was a bit of a walk to get anywhere - you had to walk through the whole casino to get to the pool area, but overall amazing and totally worth it! Much prettier than most of the other hotels I saw. LOVE the pool / beach - especially the lazy river!